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Sleep disturbance During the past 4 weeks, how often has your child had loud snoring? eath-holding spells or pauses in breathing at night? .choking or made gasping sounds while asleep? .restless sleep or frequent awakenings from sleep? Physical symptoms During the past 4 weeks, how often has your child had mouth breathing because of nasal obstruction? equent colds or upper respiratory infections? .nasal discharge or a runny nose? .difficulty in swallowing foods? Emotional symptoms During the past 4 weeks, how often has your child had mood swings or temper tantrums? .aggressive or hyperactive behaviour? .discipline problems? Daytime function During the past 4 weeks, how often has your child had excessive daytime sleepiness? .a poor attention span or concentration? .difficulty getting up in the morning? Caregiver concerns During the past 4 weeks, how often has the problems described above. used you to worry about your child's general health? .created concern that your child is not getting enough air? .interfered with your ability to perform daily activities? .made you frustrated?, for example, anti inflammatory. Howard, M.A., Gross, A., Grady, M.S., Langer, R.S., Mathiowitz, E., Winn, R., Mayberg, M.R., 1989. Intracerebral drug delivery in rats with lesioninduced memory deficits. J. Neurosurg. 71, 105112. Ibim, S.M., Uhrich, K.E., Bronson, R., El-Amin, S.F., Langer, R.S., Laurencin, C.T., 1998. Poly anhydride-co-imides ; : in vivo biocompatility in a rat model. Biomaterials 19, 941951. Jollivet, C., Aubert-Pouessel, A., Clavreul, A., Venier-Julienne, M.C., Remy, S., Montero-Menei, C.N., Benoit, J.P., Menei, P., 2004a. Striatal implantation of GDNF releasing biodegradable microspheres promotes recovery of motor function in a partial model of Parkinson's disease. Biomaterial 25, 933942. Jollivet, C., Aubert-Pouessel, A., Clavreul, A., Venier-Julienne, M.C., Montero-Menei, C.N., Benoit, J.P., Menei, P., 2004b. Long-term effect of intra-striatal glial cell line-derived neurotrophic factor-releasing microspheres in a partial rat model of Parkinson's disease. Neurosci. Lett. 356, 207210. Kirik, D., Georgievska, B., Rosenblad, C., Bj rklund, A., 2001. Delayed o infusion of GDNF promotes recovery of motor function I the partial lesion model of Parkinson's disease. Eur. J. Neurosci. 13, 15891599. Kirik, D., Georgievska, B., Bj rklund, A., 2004. Localized striatal delivery of o GDNF as a treatment for Parkinson disease. Nat. Neurosci. 7, 105110. Kordower, J.H., Chen, E.Y., Mufson, E.J., Winn, S.R., Emerich, D.F., 1996. Intrastriatal implants of polymer encapsulated cells genetically modified to secrete human nerve growth factor: trophic effects upon cholinergic and noncholinergic striatal neurons. Neuroscience 72, 6377. Krewson, C.E., Klarman, M.L., Saltzman, M.W., 1995. Distribution of nerve growth factor following direct delivery to brain interstitium. Brain Res. 680, 196206. Krewson, C.E., Saltzman, W.M., 1996. Transport and elimination of recombinant human NGF during long-term delivery to the brain. Brain Res. 727, 169181. Krewson, C.E., Dause, R., Mak, M., Saltzman, W.M., 1996. Stabilization of nerve growth factor in controlled release polymers and in tissue. J. Biomater. Sci. Polym. Ed. 8, 103117. Leong, K.W., D'Amore, P., Marletta, M., Langer, R., 1986. Bioerodible polyanhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity. J. Biomed. Mater. Res. 20, 5164. Lindner, M.D., Emerich, D.F., 1998. Therapeutic potential of a polymerencapsulated l-DOPA and dopamine-producing cell in rodent and primate models of Parkinson's disease. Cell Trans. 7, 165174. Mahoney, M.J., Saltzman, W.M., 1999. Millimeter-scale positioning of a nerve growth factor source and biological activity in the brain. Proc. Natl. Acad. Sci. U.S.A. 96, 45364539. Martinez-Serrano, A., Lundberg, C., Horellou, P., Fisher, W., Bentlage, C., Campbell, K., McKay, R.D.G., Mallet, J., Bj rklund, A., 1995. CNSo derived neural progenitor cells for gene transfer of nerve growth factor to the adult rat brain: complete rescue of axotomized cholinergic neurons after transplantation into the septum. J. Neurosci. 15, 56685680. McRae, A., Dahlstr m, A., 1994. Transmitter-loaded polymeric microspheres o induce regrowth of dopaminergic nerve terminals in striata of rats with 6-OHDA induced parkinsonism. Neurochem. Int. 25, 2733. McRae, A., Ling, E.A., Hjorth, S., Dahlstr m, A., Mason, D., Tice, T., 1994. o Catecholamine-containing biodegradable microspheres implants as a novel approach in the treatment of CNS neurodegenerative disease. A review of experimental studies in DA-lesioned rats. Mol. Neurobiol. 9, 191205. Menei, P., P an, J.M., Nerri re-Daguin, V., Jollivet, C., Brachet, P., Benoit, e e J.P., 2000. Intracerebral implantation of NGF-releasing biodegradable microspheres protects striatum against excitotoxic damage. Exp. Neurol. 161, 259272. Naumann, T., Kermer, P., Seydewitz, V., Ortmann, R., D'Amato, F., Frotscher, M., 1994. Is there a long-lasting effect of a short-term nerve growth factor application on axotomized rat septohippocammpal neurons? Neurosci. Lett. 173, 213215. Nicholas, A.P., McInnis, C., Gupta, K.B., Snow, W.W., Love, D.F., Mason, D.W., Ferrell, T.M., Staas, J.K., Tice, T.R., 2002. The fate of biodegradable microspheres injected into rat brain. Neurosci. Lett. 323, 8588. Patel, N.K., Bunnage, M., Plaha, P., Svendsen, C.N., Heywood, P., Gill, S.S., 2005. Intraputamenal infusion of glial cell line-derived neurotrophic and nicotine. O Claims data may be submitted in periodic groups batches at intervals mutually established between the intermediary and you. 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Table 1. Review of Acupuncture Points Recommended for Impotence Acupuncture Location Point Midpoint between anus and scrotum male ; or posterior labial commissure female ; Anatomy Physiological Action Condition Treated.

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NDA 21-840 Page 37 regular period. Irregular bleeding occurs most often during the first 91-day cycle of SeasoniqueTM use, tends to decrease during later cycles but may also occur after you have been taking SeasoniqueTM for some time. Such bleeding usually does not indicate any serious problems. It is important to continue taking your pills on schedule even if you are having irregular bleeding. If the bleeding lasts for more than 7 consecutive days, talk to your healthcare provider. When you take SeasoniqueTM, you need to consider the convenience of fewer expected menstrual periods 4 per year instead of 13 ; and the inconvenience of more irregular vaginal bleeding or spotting. In the primary clinical trial that determined the effectiveness of SeasoniqueTM in preventing pregnancy, the percentage of women that discontinued treatment, at least in part, due to bleeding or spotting, was 8.2 %. The following figure shows the percentage of women using SeasoniqueTM in clinical trial PSE-301 who had 7 or more days or 20 or more days of intermenstrual bleeding or spotting during each 91-day treatment cycle and nimotop. 9.B Plan of Distribution Not applicable. 9.C Market See ``9.A Listing Details.'' 9.D Selling Shareholders Not applicable. 9.E Dilution Not applicable. 9.F Expenses of the Issue Not applicable. Item 10. Additional Information 10.A Share capital Not applicable. 10.B Memorandum and Articles of Association The following is a summary of certain provisions of our Articles of Incorporation the ``Articles'' ; , and of the Swiss Code of Obligations the ``Swiss Code'' ; . This is not a summary of all the significant provisions of the Articles or of Swiss law. This summary is qualified in its entirety by reference to the Articles, which are an exhibit to this Form 20-F, and to Swiss law. 10.B.1 Company Purpose Novartis AG is registered in the commercial register of the Canton of Basel-Stadt, Switzerland under number CH-270.3.002.061-2. Our business purpose, as stated in Article 2 of the Articles, is to hold interests in enterprises in the area of health care or nutrition. We may also hold interests in enterprises in the areas of biology, chemistry, physics, information technology or related areas. We may acquire, mortgage, liquidate or sell real estate and intellectual property rights in Switzerland or abroad. 10.B.2 Directors a ; According to our Regulations of the Board the ``Board Regulations'' ; , our Directors may not participate in deliberations or resolutions on matters which affect, or reasonably might affect, the Director's interests, or the interests of a person close to the Director. In addition, while the Swiss Code does not have a specific provision on conflicts of interests, the Swiss Code does require directors and members of senior management to safeguard the interests of the corporation and, in this connection, imposes a duty of care and a duty of loyalty on such persons. This rule is generally interpreted to mean that directors and members of senior management are disqualified from participating in decisions which affect them personally. Directors and officers are personally liable to the corporation for any breach of these provisions. 141.
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